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One third of cases of early Alzheimer's do not start with memory loss

A study of the Barcelona Clinic highlights the complexity in detecting disease

About a third of Alzheimer's cases that occur both before age 60 and therefore considered early, do not have memory loss as one of the initial symptoms to detect the disease, which complicates the diagnosis.
so find a study of the Hospital Clinic of Barcelona and the Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), which publishes the magazine Tuesday of Neurology, in which researchers analyzed brain tissue from 40 donors who became ill with Alzheimer's earlier than usual.

About 10% of cases of this neurodegenerative disease occur before 65 years, but researchers now know that a good number of them present with motor, visual or speech rather than memory, and therefore half the people who started the disease with different symptoms have an inaccurate diagnosis even at the time of his death.
which if diagnosed correctly tend to take an average of three years to know that with Alzheimer's disease, an ailment with which lived about 11 years.

The research, led by neurologist Albert Lledó, notes that in 41% of the cases displayed other problems before the memory leak is present the APOE4 allele - three times more common in with a family history - which shows the importance of biomarkers to develop an early diagnosis.
Up to 4% of the population over 65 has Alzheimer's - the most common neurodegenerative disease - a percentage that doubles with each additional decade of life, researchers have pointed out.

MORE RESEARCH
The unit responsible for Alzheimer's and other cognitive disorders Clinic, José Luis Molinuelo, has also claimed the importance of providing additional funds research into biomarkers to detect this disease and the establishment of a National Plan that would achieve standards in all of Spain.

a diagnosis biomarker - genetic markers that provide insight into the latency of disease - costs between 600 and 1,000 euros per patient, recalled Molinuelo, and requires the establishment of protocols currently lacking, and also the use of these indicators is only under investigation, and only three hospitals in Spain.
In any case, has shown Molinuelo hopeful that budget adjustments do not involve a cut in this type of research, largely because it is the initiative of professionals and patients and that "no can be trimmed. "

THE IMPORTANCE OF DONATION
Neuroscientist Ellen Gelpi, Tissue Bank Neurological Clinic of the Hospital, has claimed the importance of the grant to advance research.
Currently there are over a hundred grants of this type - different from the organ - and with them researchers hope to advance knowledge of neurodegenerative diseases like Parkinson's, Huntington's or Amyotrophic lateral sclerosis (ALS), among others.