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One third of cases of early Alzheimer's do not start with memory loss

A study of the Barcelona Clinic highlights the complexity in detecting disease

About a third of Alzheimer's cases that occur both before age 60 and therefore considered early, do not have memory loss as one of the initial symptoms to detect the disease, which complicates the diagnosis.
so find a study of the Hospital Clinic of Barcelona and the Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), which publishes the magazine Tuesday of Neurology, in which researchers analyzed brain tissue from 40 donors who became ill with Alzheimer's earlier than usual.

About 10% of cases of this neurodegenerative disease occur before 65 years, but researchers now know that a good number of them present with motor, visual or speech rather than memory, and therefore half the people who started the disease with different symptoms have an inaccurate diagnosis even at the time of his death.
which if diagnosed correctly tend to take an average of three years to know that with Alzheimer's disease, an ailment with which lived about 11 years.

The research, led by neurologist Albert Lledó, notes that in 41% of the cases displayed other problems before the memory leak is present the APOE4 allele - three times more common in with a family history - which shows the importance of biomarkers to develop an early diagnosis.
Up to 4% of the population over 65 has Alzheimer's - the most common neurodegenerative disease - a percentage that doubles with each additional decade of life, researchers have pointed out.

MORE RESEARCH
The unit responsible for Alzheimer's and other cognitive disorders Clinic, José Luis Molinuelo, has also claimed the importance of providing additional funds research into biomarkers to detect this disease and the establishment of a National Plan that would achieve standards in all of Spain.

a diagnosis biomarker - genetic markers that provide insight into the latency of disease - costs between 600 and 1,000 euros per patient, recalled Molinuelo, and requires the establishment of protocols currently lacking, and also the use of these indicators is only under investigation, and only three hospitals in Spain.
In any case, has shown Molinuelo hopeful that budget adjustments do not involve a cut in this type of research, largely because it is the initiative of professionals and patients and that "no can be trimmed. "

THE IMPORTANCE OF DONATION
Neuroscientist Ellen Gelpi, Tissue Bank Neurological Clinic of the Hospital, has claimed the importance of the grant to advance research.
Currently there are over a hundred grants of this type - different from the organ - and with them researchers hope to advance knowledge of neurodegenerative diseases like Parkinson's, Huntington's or Amyotrophic lateral sclerosis (ALS), among others.

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Teledermatology can save up to 40% of consultations. Rest

Get the dermatologist's diagnosis without having to go to his office. Teledermatology not only saves the patient a trip to the hospital, but also the specialist can prevent up to 40% of patient visits. Is what concludes a study published in the English magazine 'Actas Dermo-Sifiliográficas'.

This choice of care increasingly has more arguments. Previous studies have suggested it as a solution to reduce the waiting lists of Dermatology and, now, a group of experts led by dermatologist Sergio Vañó shows how the query could relieve the dermatologist.

The key is to maintain close collaboration between primary care physicians and dermatologists emergency room. That is, the patient go to his family doctor or ER and then to capture images of skin lesions, they would be sent through intranet or e-mail to the specialist, who would be responsible to analyze and make a diagnosis.

is a methodology which is already used in some English hospitals, especially, according to an analysis conducted in 2009 by a dermatologist at the Hospital La Princesa, Diego de Argila Fernández-Durán, Madrid, Andalusia and Extremadura. As the expert noted, if this technique is no longer is instituted "a lack of resources and recognition, and also by the lack of management of certain hospitals and certain managers."

In order to demonstrate and advocate the benefits of teledermatology, the team of Sergio Vañó collected digital images and medical records of 100 patients, half from primary care and half of service Emergency Hospital Ramón y Cajal de Madrid.

- A reliable diagnostic
A total of 20 dermatologists looked at the photographs and completed a questionnaire on the diagnosis and treatment. The medical opinion was clear between 70% and 87% of cases, so that, as stressed by the doctor come to his article, "the teledermatology has high diagnostic accuracy, especially in patients referred from primary care and infectious diseases. "

As for handling, 40% were treated via tele (with the indications of general medical specialist) and 60% were referred to a specialist. "The main reason why we decided to face consultation was because" the photographs were of poor quality or because the required palpation skin disorder, skin biopsy, dermoscopy, face treatment such as cryotherapy or other reasons such as testing or contact making crops, "qualifies the dermatologist Ramón y Cajal. In some situations, it would face consultation, and patients with tumors of the skin.

Now, given the results of this study English, "would be interesting to design a test to assess whether the query is for Teledermatology more cost-effective than face to the dermatologist and establish in what situations is well to establish some indications or criteria for using this method targets, "Sergio Vañó concludes.

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five minutes and not smoking or drinking coffee, tips for blood pressure at home correctly

rest at least five minutes, not smoking, physical exercise or drink coffee before taking the stress are some tips you have included the English Society of Geriatrics and Gerontology (SEGG) in 'Ten Commandments to be correct tension' from home.

should also be assured that sphygmomanometer (device used to measure blood) is the right size, ie, a size proportional to the length of the arm, measure the voltage at the same hour, preferably in the early hours of the morning always do in a room with average temperature and put his arm horizontally at heart level, resting on a table or chair arm.

is also important not to speak or move while measurements are made, do so in the two arms and remember the higher figure and the final diagnosis is based on at least three measurements taken on two different visits and, finally, make another power sockets five minutes after the first.

occasion of the celebration of World Hypertension Day, the SEGG recalls the need to control through frequent measurements to prevent possible rise and its consequences "disastrous" since, it is a disease that has no symptoms in its early stages symptoms and often coexists with other cardiovascular risk factors such as changes in cholesterol, diabetes and obesity.

According has assured the company, this condition causes "numerous" medical consultations in older adults and is conditioned by hereditary aspects as lifestyle. It also creates many complications. Among others, increases the risk of stroke, heart failure, myocardial infarction, renal failure, aneurysms and death.
"Although proper management of hypertension resulting in substantial benefits and that the degree of knowledge and drug therapy in the general population of Spain is moderately high, there is still a high percentage of elderly who have no a regular and acceptable the tension, "said Dr Nicolas Martinez, Deputy Medical Service Geriatric Hospital de Navarra and member of the SEGG.

Taking the strain on medical visits is commonplace, but " not enough. " Thus, SEGG stressed that control" total and optimal "of the blood pressure levels is recommended that the patient is carried out regular measurements at home, the fact that, besides being a good practice because it involves the patient in the process, avoid that if measurements are taken only in consultation, may appear erroneous figures known as "white coat syndrome " consisting situations that shed blood pressure nervousness false, explained Dr. Martinez.

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What chocolate is good for health (small amount)?

Al chocolate has been linked to better blood pressure and cholesterol levels, plus other benefits attributed to heart. The issue for the month of May the "Mayo Clinic Health Letter" covers the types of chocolate that are beneficial and how they help.

raw grains cocoa with those made chocolate products are a great source of flavonoids, antioxidants that is, those plants. Concentrated cocoa beans to different components of the flavonoids, especially flavonols, which apparently protect heart health.
However, raw cocoa beans are so bitter that it is virtually impossible to eat. And processing sugar is what gives flavor to chocolate products, but part of that processing extracts the beneficial flavanols.

As a general rule, the flavonol content reflects the level of fat-free cocoa solids present in chocolate. Chocolate milk, despite its creamy texture and mild flavor, it offers many flavonols because only contains 6 percent of nonfat cocoa solids, which is why black chocolate is better, it contains 23 percent fat-free cocoa solids. However, that beats all the unsweetened cocoa that contains 82 percent.
Normally, the best alternatives to high content of black chocolate flavonols are that the first ingredient is not sugar or cocoa powder 100 percent or alkalized unsweetened (ie unprocessed Dutch). When a chocolate or cocoa Dutch go through processing, the list of ingredients mentioned that processed with some alkaline.

The point is that the more black than the chocolate, the better for heart health. However, flavonols not counteract the calories, so check the label for information on the calorie content and portion size.

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Ortorexia, the new eating disorder

are adults who have taken the philosophy of healthy eating to the extreme of only consume a minimum food selection. They become obsessive, neurotic healthy eating without realizing they are malnourished at risk of serious illness.

begins is known as the "orthorexic" extremely selective consumers in the name of health, just eat a minimum list of five or six foods. On the surface it seems a good intention: nothing processed, nothing canned, no colorful foods, none of this, nothing else.

But the list of times nothing becomes so great that they stop feeding. And give the body essential nutrients to stay healthy. From there to the disease, the step becomes smaller by the day.

Can your diet take to depression?
orthorexia The term was defined in 1997 by Dr. Steven Bratman to describe a group of his own patients with a different type of eating disorder and was not about to stop eating as in patients suffering from anorexia but eating in a selective manner obsessive.
These patients seemed to bring the social mandate that an adult should eat healthy food to the point that he would become a fixture and began to refuse most foods.

Today, 14 years later that first look, the scientific community began to recognize that this is a growing problem. There is still no recognized orthorexic number, but experts believe that number in the thousands of thousands. Duke University and the University of Pittsburgh have launched a national public register of orthorexic to start measuring the phenomenon.

treatment is essential family
And the term "orthorexia nervosa" has been recognized by publications like the Journal of the American Medical Association and Psychology Today as a new eating disorder .

In summary, the characteristics that delineate a orthorexic are
As children, limit their list of foods to a minimum.
This list is becoming smaller as it deepens the disorder.
prefer foods without color, for example, plain pasta, or fries.
usually not food or processed foods or dairy products or raw food.
are socially isolated because the other question their eating.
Over time, nutritional deficiencies can have an effect on the body similar to that causing anorexia.

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Believe me when I confess that I am not jealous of her, or your life with him. Moreover, I am comforted to be happy and not me who should bear your anger, your clutter and adventure weekends that soldier. I just want to wake him to make love in the most beast thinking about me, you are able to continue your life even need to have sex with me, or any part of my body separately. I want nothing from you than your wants and your desires. I offer to change my Will. Perhaps this sounds too poetic text to what you requested, which ultimately is nothing more than sex, but with a protagonist who had not previously appeared in this story, the discretion.

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Taking fruit juice can alter the effect of drugs

An article published by the health authorities of Peru realizes that some fruits can reduce or enhances the therapeutic action of some drugs. What you need to know.

It is well known that fruits contain vitamins and enzymes that are beneficial to health, combine pineapple, apple, orange, grapes or grapefruit may inhibit or enhance the properties and therapeutic effects of some anticoagulant drugs and antihistamines for the treatment of cancer and hypertension.

warned So Aldo Alvarez Risco, a specialist in the Directorate General of Medicines, Supplies and Drugs (Digemid) of Peru's health ministry, explaining that many people who are under treatment usually take your medicines with juice fruit without knowing that it can interact in your body in a negative way, either by diminishing the positive effects of the drugs or, conversely, potentiated, which can cause a reaction toxicity.

COMBINATIONS
pharmaceutical chemist noted that this combination can also lead to other damage to health such as hypertension (high blood pressure), thrombosis (blocked arteries) and even heart attacks therefore recommended to consult with your doctor what kind of food should take in conjunction with the administration of prescription drugs to restore their health.
"The doctor is the person qualified to determine the additional nutritional care that the patient should respect for a drug treatment, and more While the patient has the right to ask the specialist whether you should continue your normal diet or to leave out fruits and foods they can be harmful to their recovery, "said .

He added that those who are under prolonged treatments for chronic diseases will not get the same results if you continue eating your drugs with the juices of these fruits.
"While the pineapple, apple and Orange inhibit the effects of the drugs mentioned above, grapefruit and grapes act in a manner contrary enhancing its medicinal properties " said.

pineapple and apple
Aldo Alvarez Risco also explained that particularly the pineapple can inhibit the effects of some anticoagulant drugs used to prevent strokes caused by blood clots inside a blood vessel.
Meanwhile, apple juice and orange reduce the effectiveness of drugs known as fexofenadine (an antihistamine), the etoposide (anticancer) atenolol, celiprolol and talinolol (beta-blockers used in stroke prevention and treatment of hypertension) and cyclosporine (used to prevent rejection of transplanted organs).

Finally, he stated that grapefruit juice or grape juice inhibit intestinal enzyme partially destroys drugs as they are absorbed and as a result, the patient's body ends up absorbing more of the proper medication.

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Measles is back

In the early '90s, the experts thought they were close to eliminating measles forever.

Measles is a disease particularly dangerous for children, but anyone can get sick at any age.
But now, the World Health Organization (WHO) has set a date for that goal farther: 2015. However, even that seems unlikely

reason? A measles outbreak that is spreading to Europe, affecting France, Belgium, Germany, Romania and now in the UK.
Other Significant outbreaks are appearing in Serbia, Spain, Macedonia and Turkey.
In recent months, the Agency for Health Protection (HPA, an acronym in English) British agency, has seen an increase in measles cases in children and young adults in England and Wales.

Its figures show that between January and April, there were 275 cases of laboratory confirmed measles. In the same period last year, there were 33 cases.
The HPA said that these cases are "is associated with recent foreign travel or small groups of children and unvaccinated young adults aged between 10 and 24 years.

measles ABC
highly contagious disease
causes fever, cough and reddish brown spots and skin
can be infected by breathing droplets when an infected person coughs or sneezes.
Possible complications include pneumonia, ear and eye infections and diphtheria.
Serious complications include inflammation the brain (encephalitis) which can be fatal.
Measles during pregnancy can cause loss, premature delivery or low birth weight baby.

"tip of the iceberg"
The situation in France, however, is considerably worse.
The French authorities have officially declared a measles epidemic in the country, with almost 5,000 cases reported between January and March this year. The number is almost equal to the total cases reported in France, 5090, throughout 2010.
The OMS afirma que Francia está tomando medidas inmediatas para controlar los brotes, vacunando a niños a los 9 meses de haber nacido y ofreciendo vacunas a toda la gente no inmunizada arriba de esa edad.

La doctora Rebecca Martin, quien coordina el programa de la OMS de vacunación y enfermedades prevenibles en Europa, cree que el alto número de casos en Francia se debe a un exceso de confianza.
"En Francia, ya no veían la enfermedad, así que la gente pensó que no había necesidad de inmunizar a sus niños… Su percepción del riesgo cambió".

La organización that oversees public health in France, the Institut de Veille Sanitaire (Institute for Health Monitoring, INVS are his initials) is concerned.
In a newspaper article, Françoise Weber, director of INVS, estimated that the cases and confirmed by health professionals in this country are just "the tip of the iceberg."
But measles can be eliminated from Europe, says Martin, Dr. WHO.

"In the Americas, measles was eliminated in 2002. There are cases that arise there now because everyone has been immunized, therefore, es posible lograrlo. Pero es un proceso lento y necesitamos acelerar nuestros esfuerzos"

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The 13 anti-belly foods

Incorpora al menos tres de estos alimentos en cada comida principal y por lo menos uno en los tentempiés entre horas.

1. Aceite de oliva virgen extra. La mejor fuente de ácidos grasos monoinsaturados que ayudan a reducir el colesterol y potencian el sistema inmune.
2. Aguacate. Una de las pocas frutas que aportan grasas monoinsaturadas y vitamina E, protectoras y antioxidantes que ayudan a regular el apetito y controlar la ingesta fat.
3. Almonds and other nuts. The natural nuts, not roasted or salted will provide fiber, protein and monounsaturated fats that help you build muscle, reduce appetite and prevent pecking and regulate the digestive system.
4. Avena. a cereal that boosts energy and sexual appetite, reduces cholesterol and helps keep sugar levels constant. High in soluble fiber that creates a feeling of fullness and helps to eliminate metabolic waste.
5. Grains and derivatives. fulfilling and full, regulate bowel and avoid pecking.
6. Spinach and vegetable colors. neutralize free radicals, slowing aging, protect you from cancer, cardiovascular disease, osteoporosis, diabetes and obesity.
7. brightly colored fruits (red grapefruit, lemons, strawberries, watermelon, etc..) Fruits are the best natural snacks or snacks, can be carried in any bag and kept cool.
8. Eggs. a natural package of protein, vitamin B12 and vitamin A. Provide high biological value protein with all essential amino acids to help build and restore muscle mass and have a satiating effect.
9. low-fat dairy (milk, yogurt, light cheese). Calcium appears to limit the amount of new fat that accumulates in the body, also believed to have a thermogenic effect, causing increased energy expenditure in digestion.
10. legumes (chickpeas, lentils, beans, soybeans, etc..) Is traditionally associated with swollen bellies, but in fact legumes help clear your digestive system because of its high fat content.
11. blue fish (sardines, herring, salmon, tuna, etc..) sea are proteins that are associated with the famous omega-3 fatty acids, they lower levels of the hormone leptin in the body, reducing the appetite and the amount of fat stored after eating. All fish are a good alternative to meat for main course, you just have to make grilled or baked with herbs and spices.
12. Chicken, turkey and lean meats . Poultry meat is lower in fat than other meats and provides protein, iron, zinc, vitamin B6 and B12, phosphorus and potassium. The beef also provides creatine to increase muscle volume and more iron be more red. Pork is rich in monounsaturated fatty acids and has more flavor, and rabbit meat, tastier and salt and low in fat and rich in iron and vitamin B.
13. Yogurt. A dairy food can be considered alive if it is a natural yogurt bar. Avoid added sugars and sweeteners to keep the bacteria alive and reach the digestive system in top condition to repopulate the intestinal flora, improve digestion and immune system problems and reduce gas and bloating.

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Mobile Phone. New application makes possible an outpatient dialysis program.

"What is that all patients have at hand? " was what was asked a doctor to try to find a solution to the resource constraints that shared their hospital and uninsured patients with advanced renal failure, so they could perform an outpatient treatment essential to compensate for 85% or more of the role that had already lost their kidneys. The answer came immediately: a cell phone.

"The lack of adequate staff, the great dispersion of the patients in the suburbs and insecurity prevented us from making home visits necessary to assess whether housing of patients who are very poor, they met the basic conditions to get dialysis at home and leave his post at the hospital to another in a more serious condition, "said Dr. Carlos Cangado Pousa of Nephrology Department Hospital Presidente Perón, Avellaneda (Buenos Aires, Argentina).

It struck him that these home visits could be replaced with photographs taken with the phone. That would be corrected, if necessary, features housing to meet safely each step of peritoneal dialysis, which together with hemodialysis are two renal replacement therapies for people with less than 15% of renal function.

- Haemodialysis or filtering the blood, is performed three times per week for four hours in a hospital or a specialized center,
- peritoneal dialysis: is outpatient and the patient needs to repeat several times a day. It is less invasive than hemodialysis because no needles are used, but a catheter into the abdominal cavity, placing a surgeon. To filter impurities can no longer dispose of the kidneys, this therapy uses the body membrane, the peritoneum, as natural filter. Still, it is underutilized in our country: 94% of the 25,000 patients with renal replacement therapy in undergoing hemodialysis. "peritoneal dialysis prolongs residual renal function, whereas hemodialysis is lost faster -added Cangado Pousa. It is therefore very useful for kids and very good as initial therapy"

- A unique program
After teaching patients how to perform peritoneal dialysis, doctors "Public Program of Peritoneal Dialysis hospital Peron asked them to take pictures with their cell phones to the pool where levaban hands to manipulate the elements of treatment, the site where they stored the kits to receive free treatment through INCUCAI and the place they used for dialysis .
also answered a questionnaire about the services they had in the house, such as electricity and water, the level of income if they work and educational attainment. With this information, organized an electronic file for have a complete idea of \u200b\u200bthe situation of each patient.

"At first, were ashamed to show photos of their homes, "recalled Cangado Pousa. Over time, and after learning " mirror " to wash their hands as a surgeon before operating and keep out germs the body , to use surfaces that can be easily cleaned (without tablecloths, for example) and find a place without humidity or too much heat to store treatment kits, they strove to follow the advice of doctors to improve their housing conditions .
That included from up the spout kitchen sink to wash their hands, to learn to adapt a tap to a 20 liter loaded with water once a day at the spigot or garden hose in the neighborhood, or given a coat of paint to floor to prevent dust from cement.

But how could they know whether the program was working? The doctors decided to implement the quality criteria used by the International Society of Nephrology: the number of peritonitis, and infections at the catheter exit site with patients and mortality.
In a study of 26 patients in the program, the team found that on average patients had peritonitis ("Achilles heel method, "according Cangado Pousa) and an exit infection every 25 months.

The average income was 546 pesos, only six had their own home, while 15 of shared and three lived in very precarious. Regarding health services, five had no running water and four did not have a faucet in the house.

"We found that the survival of these patients is similar to that of those with adequate housing "said Cangado Pousa. With this we proved that the housing characteristics are not a limitation for peritoneal dialysis ambulatory. We also learned that the concept of health is primary, and that patients accept all suggestions and try to implement them, because they feel better. It's something that has nothing to do with poverty and destitution. "

For more information about the program Perón Hospital, for which he spent more than 100 patients, is available at: nefro.peron @ gmail.com.

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The position of your body tell about your self

A recent study relates physical position to the level of self-esteem and sense of power of people. Here we have more details on this finding and give you some recommendations to improve the perception you have of yourself to, or call self-esteem.

Luisa is very high and tends to slouch to hide her height. Alejandra, by contrast, is short and overlooked fear has developed a strong character, to be noticed. The two believe that height affects how the world perceives them and how they perceive the world.
The reality is that life itself is different in either case. Try it: Choose a landscape and stand on a chair or bench for you more height, then kneel and watch the same scene, how it looks before and after?

Just as the actual height changes the way we see the world, the attitude we adopt to walk and sit, regardless of stature, also speaks loudly about how we feel about ourselves. Added to this are other aspects such as the expression on your face, your reactions, looks, movements and other nonverbal behaviors that also speak to you.
With this in mind and following the idea that the species is the posture that indicates power or supremacy between them, a group of researchers from Columbia and Harvard universities wondered whether something similar happen between people, and found that those with expansive views (with more relaxed limbs and occupying more space in your body) had more feelings of power and a greater willingness to take risks than those with more closed and retracted positions (with the tips touching the torso and minimize the space they occupied, hunched postures or inwards).

Had you thought of this before? How do you stand and what is the perception you yourself? Self-esteem is the way you look and think to yourself a. People with healthy self-esteem feel good about themselves, appreciate their own worth and pride in their skills, abilities and achievements. People with low self-esteem, however, feel insecure, they believe that no one likes and that are not good at anything. Look at the difference of transmitting a person walking with his mind up and another that makes looking at the floor.
Self-esteem changes over time. It is therefore possible that at some point in your life you feel with low self esteem, but you're way of thinking positively, you can probably change your opinion about yourself a. Sometimes, if you can not do it alone, it is preferable that you ask for professional help to have high self-esteem that allows you to develop yourself in a healthy way in all the activities you have in everyday life.

Some studies have shown that outdoor exercise such as walking, biking and even engage in gardening, helping to raise self-esteem. And best of all is that five minutes of exposure to nature might be sufficient to give that boost your mental health.

Other recommendations to improve your self-esteem include:
Avoid having negative thoughts about yourself a. Instead of focusing on your flaws start to think about your positive aspects.
Identify what things you do not like about yourself to you can change and what not. If there is something you can change, do not expect to do, but if not possible, start working for love as you are.
Accept your mistakes and the ability to commit and see them as opportunities for learning and growth.
not try to be perfect. Some people are pressed for perfection both ending paralyzed by it.
Ponte concrete objectives and is able to meet them at the time you've proposed. Follow your plan and do not forget to record your successes and your progress.
Make new activities that allow you to develop your skills, find out make you feel better and enjoy your achievements.
Be proud of your opinions and your ideas. Express them without fear.
collaborates in some social work or helping others, even in small things. Feel you're making a and recognizing your support is one of the best ways to increase your self-esteem.
enjoys spending time with people who mean something to you and doing things you like. Do not let your insecurities will put a damper on your life.

You never too late to build a healthy and positive self-esteem. And as self-esteem influences nearly everything you do, it is important that you learn to love, to nurture and to make time to take care of you, both physically and emotionally.

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Feeling cold feet without actually what they might indicate a neurological problem

Lately, I feel I have cold feet long, but they are not touching. Could this be a symptom of something that is coming?

RESPONSE Dr. John Jones, Vascular Center, Mayo Clinic in Rochester, Minnesota, USA:
Although to clarify the exact source of the symptoms is necessary to perform a physical examination and diagnostic tests, a possible cause to feel cold feet, but actually they are, is to have a neurological problem as peripheral neuropathy.
Naturalmente, hay muchas razones para que los pies se enfríen y la más obvia es el ambiente frío, combinado a la falta de calzado adecuado o de medias. De igual manera, el sudor frecuente o constante (hiperdrosis), generalmente producto del nerviosismo o de literalmente “quedarse helado en los pies”, también puede provocar frío en los pies, sobre todo si la evaporación produce un enfriamiento rápido. Por otro lado, los pies igualmente pueden enfriarse cuando el flujo sanguíneo no es bueno en las arterias que los abastecen. Sin embargo, en todas estas circunstancias, los pies están realmente fríos al tocarlos.

Por lo general, cold sensation in the feet is benign and there is no serious underlying cause. However, feeling cold feet are not really what could indicate a nerve problem, such as peripheral neuropathy that can cause this symptom. Peripheral neuropathy occurs as a result of nerve damage or injury caused by any underlying medical disorder. Diabetes is one of the most common causes of peripheral neuropathy, although the disease can also result from a vitamin deficiency, metabolic problems, kidney disease, liver disease, and exposure to toxins. Peripheral neuropathy also be inherited and sometimes never found the cause for the disease.

Peripheral nerves are those nerves outside the brain and spinal cord (central nervous system). Peripheral neuropathy usually starts in the longest nerves in the body that are coming to the toes, hence, symptoms usually appear first in the feet and then at the bottom of the legs. Other possible symptoms of peripheral neuropathy are feeling numbness, tingling, burning or pins and needles in the feet and legs that may spread to the hands and arms as well as stabbing or burning pain and sensitivity to touch. As peripheral neuropathy progresses, a person could lose feeling, lose coordination and muscle weakness present.

You should see a doctor to evaluate your situation. If the doctor suspects a peripheral neuropathy or other nerve damage, there are several tests that could be made to discover the underlying source of the problem. To help with diagnosis, the doctor may talk to you about your medical history and perform a physical and neurological exam that would include a review of reflexes, strength and muscle tone, the ability to feel certain feelings, and their posture and coordination.

addition, you may do blood tests to check the level of vitamins, thyroid function, blood sugar levels, as well as liver and kidney function, because this can also affect nerves. In addition, your doctor may suggest you undergo an electrophysiological test, known as electromyography (EMG), and a nerve conduction study. Both tests measure the electrical signals from the peripheral nerves and how well they transmit signals to the muscles.

In some cases it may be necessary to perform a nerve biopsy (procedure that removes a small piece of a sensory nerve near the ankle to check for problems) and imaging tests such as MRI or CT scan to determine the cause nerve damage.

is important for a doctor to evaluate your situation soon. If the source of the problem was peripheral neuropathy and cold sensation in the feet just a symptom of it, you could find in the early stages of the disorder and in that case, maybe all you need would be to discover and treat the underlying cause of nerve damage. In contrast, if allowed to proceed nerve damage, the person may feel pain and other symptoms that may be more difficult to treat successfully.

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distracted people have "much brain

know that there are adults who are more easily distracted than others when performing a task.

More gray matter could indicate a more immature brain.

Now, research conducted in the United Kingdom, found that the cause could be in brain structure.
The inattentive have a greater volume of gray matter in the brain region that is responsible for maintaining attention, say scientists at the University of London.
The gray matter is an essential component of the central nervous system and is distributed on the surface of various brain regions, including those who are responsible for muscle control, sensory perception, memory and emotion.
Some theories have linked to it with information processing and reasoning, and therefore it is thought that its volume in the brain is associated with the intelligence of an individual.
But these theories have not been verified.

more gray matter, the more distracted
Now, to investigate the relationship of the volume of gray matter and the attention span, the study published in the Journal of Neuroscience (Journal of Neuroscience) , compared the brains of individuals who are easily distracted by those who hardly lose attention.
Professor Ryota Kanai and his team first analyzed the ability of distraction of a group of volunteers healthy with a questionnaire that should answer questions like: how often noticed the signs on the streets or going to the supermarket to buy something and when I got there they had forgotten what to buy, etc.

Those who were more distracted and received the highest score.
volunteers then underwent structural MRI scans.
The researchers found that the most obvious difference in brain structure of more distracted, those who had more points in the questionnaire, and the most attentive was the volume of gray matter in a region of the cerebral cortex called the superior parietal lobe (LPS) on the left.

The most distracted, scientists say, had more gray matter in this region.
later to see if this structural difference is actually due to the ability of distraction or attention of a person, the scientists asked volunteers to carry out several tasks containing various distractions.
The scientists measured the time it took individuals to perform the task both with and without distraction it.
According to Professor Kanai, the level of distraction of the person could be measured by the time it took to perform the task.

brain stimulation
subsequently repeated the experiment. But this time the scientists used a noninvasive brain stimulation called transcranial magnetic stimulation, with which you can "off " selectively the activity of regions of the cerebral cortex.
In the experiment, the researchers "off" the participants left LPS for half an hour, during which time they had to perform the same task as in the previous year.

For the study used a transcranial magnetic stimulation technique.
The results showed that the time was carrying out the task had increased 25%. That is, individuals are more easily distracted and therefore took longer.
According to Professor Kanai, this shows that the LPS plays a role in the "hierarchical control " care and tries left LPS overcome the distractions.
In the study, individuals with larger left LPS were most distracted.
Scientists do not know why it works in this way the left LPS, but believe that a greater volume of gray matter showing a less mature brain.

"As we grow and develop, the gray matter is " pruning " neurons to work more efficiently," explains researcher .
"And a greater volume of gray matter could indicate a less mature brain."
theory adds the scientist, supports the assumption that children are more easily distracted than adults.

Not everyone, however, is lost for the distracted.
Professor Kanai and his team are exploring ways to improve the standard of care in those with a large volume of gray matter.
and are testing a technique called transcranial direct stimulation, with which, they say, may be possible to stimulate the brain by sending an electrical current to LPS inadvertently left by electrodes placed in the head.

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Could a capsule camera to replace a colonoscopy?

A new technology that uses a capsule camera remote control to scan the inside of the colon could one day be an alternative to colonoscopy, according to a new study suggests.

Researchers at the Medical College of Osaka in Japan have developed a "self-propelled endoscope capsule-shaped" that can be inserted into the anus and guided through colon via a remote control and a magnetic field, capturing images on the tour.

similar cameras are currently used in capsule form for problems in the small intestine, said Dr. Durado Brooks, director of colorectal cancer for the American Cancer Society (American Cancer Society). Patients swallow the capsule, which then travels through the digestive system similar to the food, recording images from inside the intestine.

But the capsules did not work equally well to look for problems in the colon, said Brooks.
Part of the reason is that the colon has many folds. During a colonoscopy, doctors move an endoscope, or flexible tube containing a light and a camera around the inside of the colon to get a full view, something the capsule camera can not do with ease.
"The colon is not a smooth tube. It is like a pipe," said Brooks . "It is a muscular tube convoluted, with many folds and crevices. The capsule camera will be able to see behind the folds and crevices inside."

addition, the colon, although its 1.4 meters (4.5 feet) is much shorter than 6.4 meters (21 feet) of the small intestine is larger in diameter than the latter body, which makes getting a 360 degree view is more difficult.
Finally the capsule cameras currently in use are slow to move through the digestive tract. To get a good view of the colon, it should be kept clear of waste materials, including feces and mucus. Even if a patient undergoes an enema, the waste material has not yet reached the colon could end up obscuring the view for the moment when the camera comes in capsule form.

Under the new study, Japanese researchers went the wrong way, so to speak.
First, they injected water into the anus and then inserted the camera in pill form. Images were obtained using a real-time monitoring to control the device with a remote control.
capsule moved smoothly through the colon and anus could be removed easily and safely, according to the study.

"This trial demonstrates the feasibility of controlling and managing the capsule in the colon of a human awake" said in a news release from the Disease Week Digestive study author, Dr. Takanori Kuramoto. "Our study is the first trial of a video camera in the form of self-propelled capsule in the human colon, and hopefully lead to the development of a commercial system to propel the capsule so as to allow doctors to visualize the entire digestive tract the esophagus to the anus. "
The findings were presented Sunday at the Digestive Disease Week in Chicago.

Brooks said the findings were a "proof of principle", which means that researchers have shown that using the cameras in capsule form to scan the colon is possible. But much more research is needed before the devices can actually be used. This includes determining which work as well as current tests such as colonoscopy.
"The next step is to determine whether or not you can provide an accurate assessment of what happens in the colon," said Brooks .

Even if you can, a capsule camera will never replace colonoscopies, said. When doctors detect abnormalities such as polyps that can become cancer during a colonoscopy, often removed immediately.
If a capsule detects polyps, the patient will undergo a colonoscopy for polyps after being treated for biopsy.
"That can not be done with a capsule," said .

Dr. Joel Brill, medical director of the Registry of Digestive Health Outcomes of the American Association of Gastroenterology (American Gastroenterological Association), said that any device that has the potential to make colorectal cancer screening is More tolerable is a positive development.
"This seems a feasibility study," Brill said . "As researchers said, the next step is to see if you can actually sell, or get out of a field of research."

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An Argentine development. Innovative combination of drugs in a single capsule.

simplified the treatment improves the adhesion and facilitates compliance.

a drug is available in a single capsule contains an anti-inflammatory and gastric protector fails to improve treatment compliance. Argentina is a development and unique in the world with innovative technology, combined into a single capsule diclofenac and omeprazole.

The World Health Organization (WHO) estimates that adherence to long-term treatments in industrialized countries reaches only 50 percent of patients, and that adherence is even lower in developing countries developing. A lot of patients find difficulty in complying with treatment, and while many reasons have been cited for this lack of adhesion, one of the main predictors of compliance is the number of times per day the patient should take medication. Several studies suggest that simplify the treatment regimen improves adherence and facilitates compliance.

chronic conditions such as osteoarthritis (OA), rheumatoid arthritis or some sports injuries that require the use of long-term analgesics for the treatment of pain, and patients who receive pain medication regularly, mainly over 65 years and those with one risk factor, may experience symptoms such as nausea, heartburn, indigestion or pain in the stomach. Various international medical societies recommend that patients who require continuous administration of NSAIDs (NSAIDs) perform a simultaneous treatment with agents that inhibit the secretion of stomach acid as inhibitors called proton pump inhibitors (PPIs) including omeprazole.

is available in Argentina
is medicine in a single capsule contains an anti-inflammatory and proton pump inhibitors.
is a multinational development Bagó Argentina, and the only one in the world that combines innovative technology, in the same capsule, diclofenac and omeprazole. "The association of both drugs in a housing offers advantage of a smaller number of samples to be performed because the patient is generally polymedicated "said Dr. Augusto Riopedre, Argerich Hospital rheumatologist doctor and vice president of the Association of Rheumatology of the City of Buenos Aires. The combination of both drugs in one capsule simplifies decision for the patient and avoid oversights or errors in dosage, which is an advantage for greater adherence to treatment. "While the simultaneous administration of omeprazole with an NSAID reduces the risk of gastrointestinal complications, adherence of patients taking two drugs separately is suboptimal. This new combination of drugs can improve adherence and thereby achieve a more effective way to reduce the risk of complications, "said Dr. Soifer . "The advantage for adhesion is the declining number of outlets of medicines and reducing the possibility of forgetting the same schedule mainly by elderly patients," added Riopedre.

For his part, Dr. Arnoldo Albero, founder and former president of the Argentina Society of Sports Traumatology and director of the Medical Department of Women's Volleyball Team of Argentina stressed that the association of diclofenac and omeprazole a single capsule is also an option for young athletes for whom gastric protection is essential as they are subjected to stressful activities that require high physical demand. "It also allows to extend the indications of chronic inflammatory diclofenac in any patient with gastrointestinal and medicating lability elderly patients are more likely to develop gastrointestinal lesions." added.

The NSAID diclofenac is the number one and eighth best-selling drug worldwide. It is the most common analgesic used to treat pain, especially in those cases in which inflammation is the cause of it. Among its many uses, including rheumatic diseases, tendonitis, bursitis, sciatica, myalgia, headaches, sprains and strains, as well as postoperative pain, dental or gynecological conditions associated with, among others. Omeprazole is the world's most widely used drug in the treatment and prevention of gastric and duodenal ulcer disease.

- An innovative Argentine development
The new combination of drugs diclofenac and omeprazole in a single capsule, which combines technology innovatively multiparticulate systems, is a development of Laboratories Bago, Argentina a multinational presence in over 45 countries worldwide. "This product combination of two assets, is an innovative response to a therapeutic niche that does not have similar or the country or the world. Combine them into a single capsule has the important advantage that the physician may have a better monitoring of treatment efficacy and compliance with the dosing schedule, "said Dr. Luis Dall, Chemical Development by Bago Special Products.

combine to achieve both active in a single product, it was necessary to avoid different pharmaceutical and technical challenges. "The first consideration to take into account was that both active systems should be formulated as delayed release (enteric) and follow the latest market trends and from the standpoint of innovation, this system should be multiparticulates. We use two systems and enteric multiparticulates of whom were experienced: diclofenac sodium enteric enteric multiparticulates and omeprazole sodium multiparticulates " described Dall. In multiparticulate technology (multiple units totaling dose) the drug is released through small and multiple microspheres, in which each functions as a unit, allowing a more regular release and absorption of the drug during transit gastro-intestinal and less influence of the presence of food. This means a clear advantage compared to classical biopharmaceutical enteric coated tablet or capsule including enteric soft. Studies have shown that enteric multiparticulate system, compared with classic enteric tablet, provides more rapid absorption and regular assets, allowing, for its small size, one step at Agile gastric and intestinal.

In recent years, Laboratorios Bago set as one of its objectives, developing new formulations, even conventional drugs or molecules, in order to facilitate patient adherence to treatment and in some cases improve the properties of the active ingredient. "There is always a need to improve the administration of drugs whose effectiveness has been widely proven but which have some difficulties in either administration or assimilation. While there are some developments in the world that combine anti-inflammatory inhibitors, proton pump, the particular combination of diclofenac and omeprazole has not so far in the background world. " said Dr. Eduardo de la Puente, Medical Director of Laboratories Bago. "Bago In this development offers for the patient not only an advantage in taking the medication but also an economic benefit, since the cost of combination therapy with both drugs alone is greater than the product in combination," concluded the the Bridge.

- Seniors poly
People over 65 account for 10 to 25 percent of the population and consume 25 to 50 percent of prescribed drugs. It is estimated that 36 percent of older adults have more than 3 chronic diseases, which is usually translated in a "polypharmacy" it can be difficult to manage. Most of these patients are susceptible to errors and problems associated with taking drugs. The study "Medication errors and lack of adherence in the elderly", revealed that one of the main factors related to medication errors and nonadherence in patients over 65 years is the number of drugs prescribed.

For WHO, adherence to treatment in the elderly requires special attention. Although anyone at any age can remember to take medication in some patients over the memory difficulties may be exacerbated. Many older adults simultaneously receiving multiple medications for the treatment of various chronic conditions, resulting in a regimen that requires taking multiple drugs throughout the day.

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Advances in laboratory conditions of the eye caused by diabetes

An experimental work carried out by Argentine researchers failed to prevent and in some cases slow the progression of eye disease related to diabetes progression. It is diabetic retinopathy, a disease for which yet no effective therapeutic strategies, and mechanisms of prevention. The results, published in the journal The American Journal of Pathology, open new perspectives.

Diabetic retinopathy is the leading cause of irreversible blindness in adults.

"After 10 years of diagnosis of the disease of diabetes to 30 percent of patients have a marked visual impairment. In our country it is estimated that there are about 1,800,000 people with diabetes " CyTA Agency told Dr. Ruth Rosenstein, director of the Laboratory of Retinal Neurochemistry and Experimental Ophthalmology in the Department of Human Biochemistry, Faculty of Medicine of the UBA. He added: "Diabetic retinopathy is caused by arterio-venous damage may cause edema, retinal ischemia extravasation, ie, a reduction of blood flow, which has consequences for the retina, beyond depriving the tissue contribution of nutrients and oxygen. In many cases this deterioration affects the macula, the retinal area of \u200b\u200bmaximum visual acuity. It has been shown that diabetes affects different early retinal cell types, contributing to a progressive visual dysfunction. "

Currently there are no effective therapeutic strategies for prevention or reversal of diabetes-induced retinal damage, but different studies performed basic science to design new treatments. An investigation, conducted by Dr. Rosenstein -it-CONICET researcher, opens the way for the development of new therapies for the treatment of diabetic retinopathy. The results of this study were published in the journal The American Journal of Pathology.

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late nineteenth century, the philosopher Friedrich Nietzsche (1844 - 1900) proposed the now famous concept: "Whatever does not kill you makes you stronger" . "Almost a century later, scientists began to give this idea a significant 'biological meaning' , known under the name of ischemic conditioning. This conditioning is to produce a mild injury without significant consequences, which is capable of providing protection against a deep damage " Dr. Rosenstein said.

As explained by the researcher of the CONICET, the effectiveness of this strategy has been evaluated in different models of ischemia in the central nervous system with encouraging results. In the study, published in The American Journal of Pathology, Rosenstein and colleagues used an experimental model of diabetes in rats induced by injection of a drug, streptozotocin, which selectively kills pancreatic beta cells, insulin-producing . This drug causes a rapid and significant increase in glucose levels characteristic of type 1 diabetes.

Subsequently, the study authors applied subthreshold ischemic stimuli, which consisted of increased intraocular pressure for five minutes so as to cause ischemia (reduced blood flow) of very short duration "This intervention prevented progression and reversed retinal damage characteristic of this disease in rats. In this work, we developed a strategy similar to one 'vaccine against ischemia' , which is something like 'cure severe ischemia with mild ischemia,' "said Rosenstein . He concluded: "The conditioning ischemic no sólo activa mecanismos que contrarrestan la cascada de eventos que dañan la retina, sino también contribuye a ‘reprogramar’ la respuesta a la isquemia. Si bien aún resta identificar los mecanismos moleculares involucrados en la respuesta desencadenada, esperamos que su logro nos permita desarrollar estrategias farmacológicas accesibles, que posibiliten una recuperación de la función visual en pacientes con diabetes.”

La relevancia de este trabajo radica en la posibilidad de ampliar el espectro de terapias disponibles para el tratamiento de una causa frecuente de ceguera como es la retinopatía diabética. En el estudio también participaron researchers Histology Laboratory, School of Medicine, University of Morón.

In the experiment, the study authors used a dye that sticks to a protein (albumin) that is in the blood. When vessels are healthy albumin is contained within the vessels. in diabetic retinopathy (Figure B), albumin "escapes" of eye glasses because the barrier of malfunctioning vessels. As shown in the photo C , the researchers managed to prevent this complication in the rat eye.

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Techniques to remember ... improve your memory

Joshua Foer has compiled a historical and scientific study of human memory. In addition, won the title of Champion of the U.S. Memory Here his most effective strategies to improve your memory and exploit the potential of your brain.

Joshua Foer tested a variety of strategies to exercise and improve memory while researching his book Moonwalking with Einstein: The Art and Science of Remembering Everything (published in March 2011). Here we present the techniques more effective against the three most common types of problems from memory.

Problem 1: can not remember someone's name.
Solution: Pair your new friend, client, colleague, friend of your friend and so on., With a celebrity or a scandalous situation.
How it works: Often when we are introduced to someone at a party or for work, we are not really paying attention to that person (unless it looks like Orlando Bloom or favorite nephew Carlos Slim). You just have to make your brain associates the name of that person with someone famous or something ridiculous.
For example, if you know someone named Richard, you think of Richard Gere wearing a pink apron and preparing a delicious dinner (the more outrageous or funny situation, the better). The next time you meet with Richard in the office, at church, or the birthday celebrations of your laws, your brain will remember that dream romantic date with Hollywood's Hottest gigolo and be able to make an easy connection.

Problem 2: can not remember where you put your keys (and you always do).
Solution: Imagine something dramatic happens around the keys.
How it works: Say leave the keys in his jacket pocket. Imagine your jacket becomes the invisibility cloak of Harry Potter or think it is struck by spontaneous combustion. If you take the time to imagine these situations, you are very aware of where you left your keys. It works well with pens, UBS reports, and even your wedding ring (if you take it off to sleep and morning never remember where the left).

Problem 3: Forgot your entire to-do list.
Solution: The 'Memory Palace'
How it works: The 'Memory Palace' is a technique in which you view items in your list in a familiar physical (in your current home, in your childhood home.) Now make a visual tour of the place from the front door, placing the first item on your list there and follow your way through your home, placing each element in different rooms.

The trick is to draw attention to yourself. As your tasks are placed throughout the house, imagine that interact with the elements. If you need to buy sunscreen for example, imagine someone that appeals to you (may be Richard Gere again), spreading it over your body. (This trick goes back centuries, because erotic images are more memorable.)

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After a heart attack, some painkillers may increase your risk of recurrence

A recent study suggests that people who have a history of heart attack are at greater risk having another attack or even dying after taking certain types analgesic prescription or nonprescription, such as Advil, Motrin or Voltarin for a week.

Danish researchers analyzed national registries of nearly 84,000 heart attack survivors and found that those taking certain nonsteroidal antiinflammatory drugs (NSAIDs) for a week faced a risk 45 percent more likely to have another attack. The use of these drugs for three months increased the risk to 55 percent.
results support the statement by the American Heart Association in 2007 that alerted doctors on the risk of prescribing NSAIDs to patients and recommended its use only to the lowest dose for the shortest time necessary.

"These results indicate that there is an apparently safe therapeutic window for NSAIDs in patients who have suffered a previous heart attack, and questioned the safety of the recommendations of use and short-term low doses of NSAIDs " said study author Dr. Anne-Marie Schjerning Olsen, a research associate at the University of Copenhagen in Denmark.

The study appears in the online edition of Circulation, May 9.

most common NSAIDs were prescribed to participants in the study were ibuprofen (Advil, Motrin) and diclofenac (Cataflam, Voltaren). Diclofenac accounted for the highest cardiovascular risk, even much higher than rofecoxib (Vioxx), an NSAID that was banned in 2004 in the U.S. due to the high rate of heart attacks and strokes among those taking it.
The Food and Drug Administration of USA. UU. issued a warning saying that patients recovering from heart surgery should not take diclofenac.
A popular NSAID, naproxen (Aleve), was not associated with an increased risk of death or recurrent heart attack in the study, although it has been associated with gastrointestinal bleeding.

"We were surprised that the commonly used NSAIDs such as diclofenac, which in some countries is sold without a prescription and without the advice of an expert to warn of potential side effects, were linked with an increased risk and that this risk was maintained during the course of treatment, "said Olsen .
All NSAIDs block the production of the enzyme COX, which comes in two forms. Drugs that inhibit the enzyme COX-2 (which include Celebrex) have a higher chance of blood clots associated other NSAIDs that inhibit COX-1, said Dr. Elliott Antman, professor of medicine at Brigham and Women's Hospital and Harvard Medical School in Boston.

"For example, aspirin, an NSAID that has anticoagulant properties, blocking the enzyme COX-1," Antman said, "and has long been considered helpful for preventing heart attacks when used in low dose. " Antman and Olsen Both agreed that the low dose that is usually given to patients, daily aspirin may not represent an added risk for recurrence of heart attack.

Moreover, the new results "does not surprise us, and we feel really support the recommendations we have made," said Antman , who was also the author of the information about NSAIDs in 2007 of the AHA.
"We felt there was a risk in the use of NSAIDs if the patient had ischemic heart disease or were at risk for this disease... We were never convinced that these drugs were safe," said Antman .

Olsen and his team noted that the new study was limited by its observational nature, so a prospective trial random would provide greater certainty on the issue. However, the data were complete, and that came from the Danish National Patient Registry, he said, and a national registry of prescriptions recorded all medications prescribed to the public since 1997.
Among the nearly 84,000 heart attack survivors studied, with an average age of 68 years, over 42 percent had at least one prescription for an NSAID, the study said. Low-dose ibuprofen is the only nonprescription NSAIDs in Denmark, so it was unlikely that its use significantly affect the results of the study, said Olsen.

Antman noted that heart patients take NSAIDs sometimes despite the risks if you have severe pain due to other conditions such as rheumatoid arthritis or lupus. First be used non-pharmacological methods of pain relief, such as physical therapy and splints heat, or other type of medication before using NSAIDs.

"Some patients have debilitating arthritis and need to take them into account in the list [of NSAIDs], knowing that as we move into the list we move to an increasingly dangerous territory," said Antman .
"If you take an NSAID, they should continue doing so for a long time. Many doctors do not monitor the use of medications and patients continue to take a long time after overcoming his heart problem."